ACLESIN is a mixture of alkaloids, derived from roots of the Aconitum leucostomum plant.As antiarythmic drug, ACLESIN improves auricular and ventricular disturbances of heart rhythm, caused by different mechanisms. Aclesin depress conductance of impulses across auricles and Hiss-Pourkinje system, does not influence the conductivity across atrioventricular node; does not induce negative inotropic effect, arterial hypotension and cholinolytic action. Aclesin exerts local anesthetic, analgetic, anti-inflammatory and sedative actions. Administered per os, drug acts after 30-50 min intervals and therapeutic effect lasts for nearly 8 hours. Repeated application does not lead to diminishing of antiarrhythmic effect.The drug is prescribed for patients with ventricular and supraventricular extrasystolias, auricular paroxysmal flutter, paroxysmal supraventricular and ventricular tachycardia, for Wolf-Parkinson-White syndrome. The drug is also used for arrhythmias that accompany the myocardial infarction and different chronic circulatory diseases.Having compared with existing antiarrhythmic drugs, ACLESIN is more effective drug for treatment of patients with chronic and dangerous for life ventricular tachyarythmias. Preparation is more effective than Quinidine, Disopyramide, Cordarone (Amiodarone) , Aethmozine and Aethacizine. Aclesin, in comparison to the other drugs, has notable advantages, as it can also be used in cases of sinus bradycardia syndrome of sinonodal weakness, syndrome of widety of interval Q-T and on phone of low arterial pressure. Long-term application of ACLESIN does not result in tachyphylaxia, arythmogeneity and other cardiotoxic effects, toxic influences on inner organs, hemapoetic system and sensation organs. For the patients with cardiac insufficiency ACLESIN practically does not influence on contractile functions of myocard, which is important advantage when compared to other antiarrhythmic drugs.Available in substance, and tablets.
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