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Tadalafil
TadalafilChemical Name: CialisSynonyms: IC 351;CIALIS;ICOS 351;TADALAFILCAS No: 171596-29-5 CBNumber: CB2236841Molecular Formula: C22H19N3O4Molecular Weight: 389.341 Purity: 99% Assay:99%Storage: Shading, confined preservation Packing: 1kg/bag Quality standard: USP31/BP2005 Description: White Crystalline Powder Storage: Shading, Confined PreservationUsage: Used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitorDescription:Cialis (Tadalifil citrate), a phosphodiesterase type 5 inhibitor, is used to treat erectile dysfunction (ED) and decreased libido in males. Cialis works by aiding relaxation of blood vessels and increasing blood flow in the penis during sexual arousal, resulting in improved erectile function. Cialis is much longer lasting than Viagra. Effects can be felt anywhere between 36-48 hours.Background: The FDA approved Cialis as a medicine for ED on November 21, 2003. It is available through prescription for those who are diagnosed with impotence. In 1998, ICOS Corporation, and Eli Lilly and Company, began manufacturing Cialis, which is available orally in 5mg, 10mg and 20mg tablets. It is also widely available by many research companies and underground labs.Action: Tadalafil improves erectile function significantly, possibly increase testosterone through increased sexual activity, and is very safe.There are limited side effects associated with its use. The most common side effects are headache, upset stomach, back pain, and muscle aches, and usually subside with in a few hours.Technical Data: In a six month study on men with erectile dysfunction ranging from mild to severe, 20 mgs of Cialis or placebo was administered to subjects as needed. It was discovered that Tadalafil improved ED compared to placebo. Ability to achieve erection and sucessful intercourse was 73% greater in those reciving Cialis verses the placebo group (1). Cialis was administered three times per week for an extended period of time, it was found to be extremely safe and very limited side effects were experienced, if any.Cialis was also linked to increased testosterone levels in a one month study where testosterone levels were found to be significantly higher at the end of the month, due to increased sexual activity.Application: Although sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis) all work by inhibiting PDE5, tadalafil's pharmacologic distinction is its longer half-life (17.50 hours) - compared to sildenafil (4.0-5.0 hours) and vardenafil (4.0-5.0 hours) - resulting in longer duration of action, and so partly responsible for "The Weekend Pill" sobriquet. Furthermore, the longer half-life is the basis for current investigation of tadalafil's daily therapeutic use in relieving pulmonary arterial hypertension. Sildenafil is approved in several world regions as a thrice-daily therapy for pulmonary arterial hypertension.
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