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Химические вещества и материалы /  Прочие изделия и компоненты химической промышленности / 
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Компания:
Wuhan Yuancheng Technology Development Co., Ltd
 
Адрес:
496#Zhongshan Road Wuchan,Wuhan,China
 
Телефон:
+86-027-50756139

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Product name:2, 4 DinitrophenolCAS NO: 51-28-5EINECS: 200-087-7MF: C6H4N2O5MW: 184.11Synonyms 2, 4-dinitrophenol, reagent grade; 2, 4-DINITROPHENOL, 1X1ML, MEOH, 5000UGM L; 2, 4-DINITROPHENOL PESTANAL, WITH APPROX.; 2, 4-Dinitrophenol, PhIndicator; 2, 4-DinitroPhenolIndicatorGr; 2, 4-Dinitrophenol97%EINECS 200-087-7Appearance: Light yellow crystal powderAssay:99%Description:The pharmacologic treatment of obesity has been challenging. Previously, amphetamine derivatives, such as dexflenfluramine, fenfluramine and phentermine, were used as centrally active appetite suppressants; however, their use is associated with valvular heart disease and the development of pulmonary hypertension. Sibutramine , a newer centrally active appetite suppressant and the lipase inhibitor orlistat are currently being used as 'diet pills', but have unpleasant side effects. However, for the majority of individuals with morbid obesity (body mass index >35 kg/m2), obesity surgery  is often the treatment modality of choice, particularly in those associated severe co-morbidities . Regular use of 2,4-dinitrophenol (DNP) is reported to cause rapid loss of weight, but unfortunately is associated with an unacceptably high rate of significant side effects .The first death due to DNP (C6H4N2O5) was reported in 1918 and was secondary to occupational exposure . Currently marketing of DNP, which is predominately through the internet, is targeted towards primarily body builders who are attempting to lose fat but retain muscle bulk. Additionally, it is widely available on the internet and is marketed as a 'safe weight loss' drug. Individuals are able to purchase 'large quantities', such as kilograms of DNP powder or hundreds/thousands of DNP-containing tablets. There are many regimes for taking the drug, all of which rely on the metabolic stimulatory effects of the drug . It has a small therapeutic index and is extremely dangerous in overdose. In this review, we will summarise the pharmacology of DNP, the potential mechanisms for its toxicity and the clinical evidence of harm associated with the use of DNP
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