Metabolism boost Hydrocortisone Good effects in promoting the breakdown of fat and treating rheumatoid diseasesSynonyms: 11beta-HydrocortisoneCAS：50-23-7EINECS: 200-020-1Molecular Formula: C21H30O5Molecular Weight: 362.5Product Implementation Quality Standard: USP, EPChemical Properties: crystalline white powderUsage: Biochemical studies,adrenal cortex hormones drugs.Glucocorticoid,antiinflammatory.Cortisol,or Hydrocortisone,is a steroid hormone,more specifically a glucocorticoid,produced by the zona fasciculata of the adrenal gland.Cortisol is released in response to stress and a low level of blood glucocorticoids.Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system;and aid in fat, protein and carbohydrate metabolism.Hydrocortisone(INN,USAN,BAN)is a name for cortisol when it is used as a medication. Hydrocortisone is used to treat people who lack adequate naturally generated cortisol.It is on the World Health Organization's List of Essential Medicines needed in a basic health system.Main functions in the body Metabolic response In the early fasting state,cortisol stimulates gluconeogenesis(the formation of glucose),and activates anti-stress and anti-inflammatory pathways.Cortisol also plays an important,but indirect,role in liver and muscle glycogenolysis, the breaking down of glycogen to glucose-1-phosphate and glucose.This is done through its passive influence on glucagon.Additionally, cortisol facilitates the activation of glycogen phosphorylase,which is necessary for epinephrine to have an effect on glycogenolysis.In the late fasting state,the function of cortisol changes slightly and increases glycogenesis.This response allows the liver to take up glucose that is not being used by the peripheral tissue and turn it into liver glycogen stores to be used if the body moves into the starvation state.Elevated levels of cortisol,if prolonged,can lead to proteolysis(breakdown of proteins)and muscle wasting. Several studies have shown that cortisol can have a lipolytic effect(promote the breakdown of fat).Under some conditions,however,cortisol may somewhat suppress lipolysis.Immune responseCortisol prevents the release of substances in the body that cause inflammation.It is used to treat conditions resulting from over activity of the B-cell-mediated antibody response.Examples include inflammatory and rheumatoid diseases,as well as allergies.Low-potency hydrocortisone, available as a non-prescription medicine in some countries,is used to treat skin problems such as rashes,and eczema.It inhibits production of interleukin(IL)-12, interferon(IFN)-gamma,IFN-alpha and tumor-necrosis-factor(TNF)-alpha by antigen-presenting cells(APCs)and T helper (Th)1 cells,but upregulates IL-4, IL-10, and IL-13 by Th2 cells. This results in a shift toward a Th2 immune response rather than general immunosuppression. The activation of the stress system (and resulting increase in cortisol and Th2 shift) seen during an infection is believed to be a protective mechanism which prevents an over activation of the inflammatory response.Cortisol can weaken the activity of the immune system. Cortisol prevents proliferation of T-cells by rendering the interleukin-2 producer T-cells unresponsive to interleukin-1 (IL-1), and unable to produce the T-cell growth factor (IL-2).[11] Cortisol also has a negative-feedback effect on interleukin-1.Though IL-1 is useful in combating some diseases; however, endotoxic bacteria have gained an advantage by forcing the hypothalamus to increase cortisol levels (forcing the secretion of CRH hormone, thus antagonizing IL-1). The suppressor cells are not affected by glucosteroid response-modifying factor (GRMF), so the effective setpoint for the immune cells may be even higher than the setpoint for physiological processes (reflecting leukocyte redistribution to lymph nodes, bone marrow, and skin). Rapid administration of corticosterone (the endogenous Type I and Type II receptor agonist) or RU28362 (a specific Type II receptor agonist) to adrenalectomized animals induced changes in leukocyte distribution. Natural killer cells are affected by cortisol.Cortisol stimulates many copper enzymes (often to 50% of their total potential), probably to increase copper availability for immune purposes. This includes lysyl oxidase, an enzyme that cross-links collagen and elastin. Especially valuable for immune response is cortisol's stimulation of the superoxide dismutase, since this copper enzyme is almost certainly used by the body to permit superoxides to poison bacteria.
Metabolism boost Hydrocortisone Good effects in promoting the breakdown of fat and treating rheumatoid diseasesSynonyms: 11beta-HydrocortisoneCAS：50-23-7EINECS: 200-020-1Molecular Formula: C21H
Quick Detail: Product name Metandienone Factory Supplying Other name Dianabol CAS register number 72-63-9 EINECS 200-787-2 Molecular formula C20H28O2 Molecular weight 300.43512 Molecular structu
Quick Detail: Product name Metandienone Factory Supplying Other name Dianabol CAS register number 72-63-9 EINECS 200-787-2 Molecular formula C20H28O2 Molecular weight 300.43512 Molecular structu
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