Sildenafil CitrateSynonyms: VIAGRA; uk92480-10CAS: 139755-83-2MF: C28H38N6O11SMW: 666.7Assay: 98%-101Melting point 187-189°C %Grade: Pharmaceutical Grade Storage: Shading, confined preservationChemical Properties: White SolidUsage: An orally active selective type 5 cGMP phosphodiesterase inhibitorDosage: As with all prescription drugs, proper dosage is at the discretion of a licensed medical doctor. The dose of sildenafil for erectile dysfunction is 25 mg to 100 mg taken not more than once per day between 30 minutes and 4 hours prior to sexual intercourse. Description: Viagra treats erectile dys function and works by relaxing muscles and increases blood flow to particular areas of the body (in this case, the penis, specifically). Its effects last up to four hours. The most common side effects of Viagra are headache, facial flushing, and upset stomach. Rarely, blurred vision, or sensitivity to light may briefly occur.As well as treating impotence, Sildenafil Citrate can also be effective in treating Pulmonary Arterial Hypertension (PAH). Similarly to how it acts to relax muscles of the penis, it relaxes arterial walls; therefore, reducing resistance and pressure in the arteries.Sildenafil Citrate is solely active in relaxing muscles and increasing blood flow to the heart, lungs and penis due to PDE-5, yet vasodilation is not increased in other parts of the body.Technical Data: In studies where Viagra was administered to over 3700 patients, 19-87 years old in world wide clinical trials. More than 550 patients received treatment post 1 year. 2.5% of the Viagra subjects and 2.3% of the placebo subjects reported adverse effects, which were all considered mild. These reported side effects included abnormal or blurred vision and increased sensitivity to light. All other negative reactions reported, including URI, flu symptoms, back pain and arthralgia, occurred at a rate of less than 2% and equally common in the placebo and Viagra administered groups. Effects worsened and were reported more frequently as dosages increased.Other studies measured duration of sexually stimulated erection using a Rigiscan device. Duration of rigidity was increased by 60% with Viagra use.Applications:In 16 separate 4-24 week trials of men (over 18 years old) who suffered from impotence for longer than 6 months, dosages between 10-200 mgs were administered. Significant improvements in erectile function, including frequency of penetration as well as erection duration post penetration, were reported with Sildenfil treatment compared to the placebo group.Erections were improved in 72% of the Viagra group verses 18% of the placebo group. In all cases effects were dependant upon dosage and improvement was the greatest when dosage exceeded 100 mgs. Responses were decreased by 40-60% in patients suffering from diabetes and prostatectomy, respectively. Withdrawal rates were less than 5% related to negative side effects and limited response rates.
Sildenafil MesylateCAS: 139755-91-2Assay: 99% min. Molecular Formula: C22H30B6O4S. CH3SO3HMolecular Weight: 570 Packing:foil bags,1kg net/foil bag, 5kg/drum.Appearance: White or white crysta
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