Male hormone Testosterone UndecanoateFor male sexual dysfunction, aplastic anemiaProduct name: Testosterone UndecanoateSynonym:Testosterone Undecanoilate;andriolCAS No.: 5949-44-0Einecs No.:227-712-6M.F.: C30H48O3M.W.: 456.7Assays: 98.57%Packing: foil bagReference Standard: BP2005Appearance: White Crystal Or White Crystalline PowderUsage: Male hormone, for male sexual dysfunction, aplastic anemia.Description :Testosterone undecanoate is a long-acting man-made version of testosterone, the natural male sexual hormone. Testosterone is responsible for the normal growth and development of male sex organs and characteristics. It includes growth and development of male organs of penis, testicles, prostate, body hair, vocal cord thickening, and muscle and fat distribution. Testosterone undecanoate contains a hormone which is similar to the hormone testosterone that is produced by the body. Testosterone is a male sex hormone that is responsible for the development of male characteristics. These include growth of hair on the face and body, deepening of the voice, muscle development and the development of the male genitalia. Testosterone is also important for maintaining libido and fertility in men. In men who do not produce enough testosterone, Testosterone undecanoate is used to reduce the effects of a low level of testosterone. Aveed (testosterone undecanoate) injection contains testosterone undecanoate (17β-undecanoyloxy-4-androsten-3-one) which is an ester of the androgen, testosterone.Testosterone undecanoate is a white to off white crystalline substance. The empirical formula of testosterone undecanoate is C30H48O3 and a molecular weight of 456.7. Aveed is a clear, yellowish, sterile oily solution containing testosterone undecanoate,a testosterone ester, for intramuscular injection. Applications :Testosterone Undecanoate (Andriol) is a unique oral testosterone product, developed by the international drug firm Organon. One of the more recently developed anabolic steroids, Andriol first became available in the early 1980's. This compound contains 40 mg of testosterone undecanoate, based in oil (oleic acid) and sealed inside a capsule. Subtracting the ester weight, this equates to a dosage of approximately 25mg of raw testosterone per cap. The design of this steroid is quite different from that of most oral steroids. Drugs administered orally generally enter the blood stream through the liver. When a steroid compound is given this way without some form of structural protection, it will be quickly broken down during the "first pass". This process leaves very little steroid intact, basically deactivating the drug. Adding a methyl group (c-17 AA) to the structure is one way to protect it from this process, however stress is also placed on the liver as a result. In some instances this stress can lead to actual damage to liver tissues, so the designers of this steroid sought another way to protect the testosterone molecule. With Andriol, this was accomplished by making a form of testosterone that would be absorbed through the lymphatic system. This is due to its high fat solubility brought about by the ester, and its suspension in oil. Having the compound absorbed this way was thought to be very advantageous, as it allows the steroid to bypass the destructive first-pass through liver. This should permit the compound to enter the blood stream intact, without the need for a harsh chemical alteration. The ester breaks off once it is in circulation of course, yielding free active Pharmacokinetics of Orai Testosterone testosterone. In design this steroid appears to be undecanoate that of a completely liver safe and orally active form of testosterone.
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