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1. Quick Detail:
Product Name: Pizotifen
Synonyms: Sandomigran; Sanomigran; 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methylpiperidine
CAS: 15574-96-6
EINECS: 239-632-9
MF: C19H21NS
MW: 295.4417
Assay: 98%
Appearance: White powder
Density 1.164g/cm3
Boiling point 436.7°C at 760 mmHg
Refractive index 1.63
Flash point 217.9°C
Vapour Pressur 7.92E-08mmHg at 25°C
2. Descriptions:
The main medical use for pizotifen is for the prevention of vascular headache including migraine and cluster headache. Pizotifen is one of a range of medications used for this purpose, other options include propranolol, topiramate, valproic acid and amitriptyline. While pizotifen is reasonably effective, its use is limited by side effects, principally drowsiness and weight gain, and it is usually not the first choice medicine for preventing migraines, instead being used as an alternative when other drugs have failed to be effective. It is not effective in relieving migraine attacks once in progress. Pizotifen has also been reported as highly effective in a severe case of erythromelalgia, a rare neurovascular disease that is sometimes refractory to the other drugs named above.
Other applications for which pizotifen may be used include as an antidepressant, or for the treatment of anxiety or social phobia. Animal studies also suggest that pizotyline could be used in the treatment of serotonin syndrome or MDMA overdose in a similar manner to the closely related antihistamine/antiserotonin drug cyproheptadine.
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