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Product Name: Demeclocycline hydrochloride Synonyms: 7-chloro-4-dimethylamino-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxamide hydrochloride;7-CHLORO-6-DEMETHYLTETRACYCLINE HYDROCHLORIDE;DEMECLOCYCLINE;DEMECLOCYCLINE HYDROCHLORIDE;6,10,12,12a-pentahydroxy-1,11-dioxo-ydro-monohydrochloride;declomycinhydrochloride;demethylchlorotetracyclinehydrochloride;demethylchlortetracyclinehydrochloride CAS: 64-73-3 MF: C21H21ClN2O8.ClH MW: 501.32 EINECS: 200-592-2 Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Chiral Reagents mp >245°C (dec.) storage temp. -20°Csolubility H2O: 20 mg/mL, clear, very deep greenish yellowform powderMerck 13,2905 Chemical Properties Yellow Solid Usage Antibacterial;Ribosomal protein synthesis inhibitor Usage Demeclocycline hydrochloride is a salt prepared from demeclocycline taking advantage of the basic dimethylamino group which protonates and readily forms a salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, demeclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis. Usage An antibiotic related to tetracycline and produced by streptomyces aureofaciens. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time .
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