beta-Amyloid (1-42) human CAS:107761-42-2
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CAS:107761-42-2
Product Name: Beta-Amyloid (1-42), Ultra Pure, HFIP
Sequence: Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala- Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
Storage: -20°
Molecular Mass: 4514.1 4
Peptide Purity: 98%
Counter Ion: HFIP treated
Supplied As: No salt, as HFIP desalts the sample.
Recombinant. A DNA sequence encoding the human beta-amyloid (1-42)sequence was expressed in E. Coli.
Description:
Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimer's patients, is thought to be the cause of Alzheimer's Disease (AD)1-3. AD is the most common neurodegenerative disease and afflicts about 10% of the population over 60 4. The abeta, HFIP is described in Stine, et. Al. 3.
1) Yankner, BA, et. Al., (1990) Science, 250: 279-282
2) Selkoe, D. J., (2001) Physiol. Rev, 81: 741-766
3) Stine, W. B. Et. Al., (2003) J. Biol. Chem, 278: 11612-11622
4) Frank, R. A., et. Al., (2003) Neurobiology of Aging, 24: 521-536
HPLC REPORT:
Product Name: Beta-Amyloid(1-42), HFIP
Column: 4.6*250mm, SP-300-5-C4-BIO
Solvent A: 0.1%Trifluoroacetic in 100% Acetonirile
Solvent B: 0.1%Trifluoroacetic in 100% Water
Flow rate: 1.0ml/min
Wavelength: 220nm
RankTimeNameConc. Area
18.000 0.3194914
29.959 1.07116490
310.519 98.231514485
411.018 0.27914298
Total 1001540187
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